Matrix metalloproteinases and atherosclerosis
نویسندگان
چکیده
منابع مشابه
Role of Matrix Metalloproteinases in Atherosclerosis: Pathophysiological and Therapeutic Implications
Atherosclerosis continues to cause considerable morbidity and mortality in the Western countries. In response to cardiovascular risk factors, a cascade of compensatory structural events occurs within the vessel wall. It has become increasingly evident that significant alterations in the structure and composition of the extracellular matrix (ECM) play a key role in the atherogenic process. Far f...
متن کاملMatrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis.
M atrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, which are highly activated by inflammatory signaling, including that of angiotensin II (Ang II; Figure). Activated MMPs are able to degrade col-lagen, elastin, and other extracellular molecules, 2 probably resulting in aging, hypertension, and atherosclerotic effects within the arterial wall (for reviews). The modi...
متن کاملAliskiren Inhibits Neointimal Matrix Metalloproteinases in Experimental Atherosclerosis.
BACKGROUND The renin-angiotensin system (RAS) plays an important role in atherosclerosis. Acting via the angiotensin II receptor, type 1, oxidative stress increases and contributes to endothelial dysfunction and vascular inflammation. Renin exerts effects through a renin receptor causing an increase in the efficiency of angiotensinogen cleavage and facilitates angiotensin II (Ang II) generation...
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results based on the recent researches, certain mmps play critical role in breast cancer initiation, invasion, and metastasis. they can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. conclusions in summary, the results ...
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Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...
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ژورنال
عنوان ژورنال: Postępy Higieny i Medycyny Doświadczalnej
سال: 2011
ISSN: 1732-2693
DOI: 10.5604/17322693.931536